The main objective of the present research was to formulate and evaluate extended release matrix tablets of antihypertensive drug Felodipine (FEL). The various batches of extended release tablets were prepared using different concentrations of Kollidon SR and HPMC K 15 and in-vitro release was compared with innovator tablet. Coating of the optimized batch was done using Opadry seal coat and sunset yellow because FEL has problem of light as well as moisture sensitivity. The extended release tablets were prepared by direct compression method and formulated using different polymer ratios. Hydrophilic polymer likeHydroxypropyl methylcellulose K15M (15-35%) and hydrophobic polymer like Kollidon SR (10-305%) were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated for hardness, friability,weight variation, drug content, swelling index and in vitro release study. The optimized formulations were selected on the basis of acceptable tablet properties and in vitro drug release compared with innovator tablet. Optimized betch tablet were coated using Opadry seal coat and sunset yellow by Pan coating method to give protection against light and moisture. Accelerated stability study was performed on optimized batch. The resulting formulation produced robust tablets with optimum hardness, consistent weight uniformity and friability. Tablets containing only Kollidon SR was not give similar release profile with innovator tablet. Addition of hydrophilic polymer and optimization of their concentration gave similar release profile with innovator tablet. The optimized tablets exhibited gradual and extended release of drug up to 12 hr. The results of dissolution studies indicated that formulation F2 (KSR-40mg and HPMC-50mg) and F7 (KSR-60mg and HPMC-30mg), exhibited drug release pattern very close to innovator release profile. So. From that F10(KSR-50mg and HPMC-50mg) was prepared, exhibited same release profile to that of innovator product.The optimized formulation F10 showed diffusion-dominated drug release coupled with erosion. From the obtained results it was concluded that the release of Felodipine from matrix tablets depends on the percent of polymers in the tablet. From the experimental data, an optimal formulationwas developed which has proved to be similar with the dissolution profile of the chosen innovator product and which was protected against light and moisture by opadry seal coat and sunset yellow.
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